June 2010 Archives
Yann
Heuzé1
1Department of Anthropology, The Pennsylvania State University, PA, USA.
3St. John's Mercy Children's Hospital, St Louis MO, USA
4Washington University School of Medicine, Saint Louis MO, USA
5Department of Neurological Surgery, University of California Davis, Sacramento
CA, USA
Premature closure of the sagittal suture
occurs as an isolated (nonsyndromic) birth defect, or as a syndromic anomaly in
combination with other congenital dysmorphologies. The genetic causes of
sagittal nonsyndromic craniosynostosis (NSC) remain unknown. Though variation
of the dysmorphic (scaphocephaly) skull shape of sagittal NSC cases has been
acknowledged, this variation has not been quantitatively studied in 3D. We have
analyzed the computed tomography skull images of 43 infants (aged from 0.9 to 9
months) with sagittal NSC using anatomical landmarks and semilandmarks to
quantify and characterize the within-sample phenotypic variation. Suture
closure patterns were defined by dividing the sagittal suture into three
sections (anterior, central, posterior) and coding each section as
"closed" or "fused". Principal components analysis of the
Procrustes shape coordinates representing skull shape of 43 cases of NSC did
not separate individuals by sex, chronological age, or dental stages of
deciduous maxillary first molar. However, analysis of suture closure pattern
allowed separation of these data. The central section of the sagittal suture
appears to be the first to fuse. Then, at least two different developmental
paths towards complete fusion of the sagittal suture exist; either the anterior
section or the posterior section is the second to fuse. Results indicate that
according to the sequence of sagittal suture closure patterns, different
craniofacial complex shapes are observed. The relationship between craniofacial
shape and suture closure indicates not only which suture fused prematurely (in
our case the sagittal suture), but also the pattern in which the suture closes.
Whether these patterns indicate differences in aetiology cannot be determined
with our data and requires analysis of longitudinal data, most appropriately of
animal models where prenatal conditions can be monitored.
Look for cool baboon graphics from this project on the cover of the September issue of AJPA!
See http://www.hominid.psu.edu for additional information on this project.
The Economist commented on the paper in their May 20 issue through their article "To Get the Girl - Fighting off Rivals May be Responsible for Masculine Traits". See link to this article
http://www.economist.com/science-technology/displaystory.cfm?story_id=16160490
Dr. Puts replies to the comments received by the publication in the May 24 issue of The Economist. See link below for his comments.
http://www.economist.com/user/David_Puts/comments
Penn State Live also reported on the paper in their May 13 issue. See link below:
