The Phillips Group

Penn State Publications


Link to Amplified Responses in Materials Using Linear Polymers that Depolymerize from End-to-End When Exposed to Specific Stimuli

34. "Amplified Responses in Materials Using Linear Polymers that Depolymerize from End-to-End When Exposed to Specific Stimuli", Phillips, S. T.*; Robbins, J. S.; DiLauro, A. M.; Olah, M. G. J. Appl. Poly. Sci., 2014, DOI: 10.1002/app.40992. Link to PDF.

Link to:  Continuous Head-to-Tail Depolymerization: An Emerging Concept for Imparting Amplified Responses to Stimuli-Responsive Materials

33. "Continuous Head-to-Tail Depolymerization: An Emerging Concept for Imparting Amplified Responses to Stimuli-Responsive Materials", Phillips, S. T.*; DiLauro, A. M., ACS Macro Lett., 2014, 2014, 3, 298–304. Link to PDF.

32. "The expanding role of paper in point-of-care diagnostics", Phillips, S. T.*; Lewis, G. G., Expert Rev. Mol. Diagn., 2014, DOI: 10.1586/14737159.2014.88744. Link to PDF.

Link to: A Point-of-Use Assay That Measures Heavy Metal Contamination in Water Using Time as a Quantitative Readout

31. "A Point-of-Use Assay That Measures Heavy Metal Contamination in Water Using Time as a Quantitative Readout", Lewis, G. G.; Robbins, J. S.; Phillips, S. T.*, Chem. Commun., 2014, 50, 5352–5354. Link to PDF.

Link to: Quantitative Fluorescence Assays Using a Self-Powered Paper-Based Microfluidic Device and a Camera-Equipped Cellular Phone

30. "Quantitative Fluorescence Assays Using a Self-Powered Paper-Based Microfluidic Device and a Camera-Equipped Cellular Phone", Thom, N. K.; Lewis, G. G.; Yeung, K.; Phillips, S. T.*, RSC Adv., 2014, 4, 1334–1340. Link to PDF.

Link to: A Rapid Point-of-Care Assay Platform for Quantifying Active Enzymes to Femtomolar Levels Using Measurements of Time as the Readout

29. "A Rapid Point-of-Care Assay Platform for Quantifying Active Enzymes to Femtomolar Levels Using Measurements of Time as the Readout", Lewis, G. G.; Robbins, J. S.; Phillips, S. T.*, Analytical Chemistry, 2013, 85, 10432–10439. Link to PDF. Highlighted in: The Wall Street Journal, Science Daily, Phys.Org, and others.

Link to: mproving the Accessibility of Responsive End-Caps in Films Composed of Stimuli-Responsive Depolymerizable Poly(phthalaldehydes)

28. "Improving the Accessibility of Responsive End-Caps in Films Composed of Stimuli-Responsive Depolymerizable Poly(phthalaldehydes)", DiLauro, A. M.; Zhang, H.; Baker, M. S.; Wong, F.; Sen, A.; Phillips, S. T.*, Macromolecules, 2013, 46, 7257–7265. Link to PDF.

Link to: A Self-Powered Polymeric Material that Responds Autonomously and Continuously to Fleeting Stimuli

27. "A Self-Powered Polymeric Material that Responds Autonomously and Continuously to Fleeting Stimuli", Baker, M. S.; Yadav, V.; Sen, A.*; Phillips, S. T.*, Angew. Chem. Int. Ed., 2013, 52, 10295–10299. Link to PDF. Highlighted in: Nature Chemistry, Chemviews, Phys.org, Inovations-Report, e! Science News.

Link to: End-Capped Poly(benzyl ethers): Acid and Base Stable Polymers That Depolymerize Rapidly from Head-to-Tail in Response to Specific Applied Signals

26. "End-Capped Poly(benzyl ethers): Acid and Base Stable Polymers That Depolymerize Rapidly from Head-to-Tail in Response to Specific Applied Signals", Olah, M. G.; Robbins, J. S.; Baker, M. S.; Phillips, S. T.*, Macromolecules, 2013, 46, 5924–5928. Link to PDF.

Link to: Using Depolymerizable Poly(carbamates) to Increase the Sensitivity of Quantitative Time-Based Assays in Paper Microfluidic Devices

25. "Phase-Switching Depolymerizable Poly(carbamate) Oligomers for Signal Amplification in Quantitative Time-Based Assays", Lewis, G. G.; Robbins, J. S.; Phillips, S. T.*, Macromolecules, 2013, 46, 5177–5183. Link to PDF.

Link to: Reagents and Assay Strategies for Quantifying Active Enzyme Analytes Using a Personal Glucose Meter

24. "Reagents and Assay Strategies for Quantifying Active Enzyme Analytes Using a Personal Glucose Meter", Mohapatra, H.; Phillips, S. T.*, Chem. Commun., 2013, 49, 6134–6136. Link to PDF.

23. "Advances in Materials that Enable Quantitative Point-of-Care Assays", Phillips, S. T.*; Lewis, G. G., MRS Bulletin, 2013, 38, 315–319.

Link to: Stimuli-Responsive Core-Shell Microcapsules With Tunable Rates of Release by Using a Depolymerizable Poly(phthalaldehyde) Membrane

22. "Stimuli-Responsive Core-Shell Microcapsules With Tunable Rates of Release by Using a Depolymerizable Poly(phthalaldehyde) Membrane", DiLauro, A. M.; Abbaspourrad, A.; Weitz, D. A.; Phillips, S. T.*, Macromolecules, 2013, 46, 3309–3313. Link to PDF.

Link to: Effect of Aromaticity on the Rate of Azaquinone Methide-Mediated Release of Benzylic Phenols

21. "Effect of Aromaticity on the Rate of Azaquinone Methide-Mediated Release of Benzylic Phenols", Schmid, K. M.; Phillips, S. T.*, J. Phys. Org. Chem., 2013, 26, 608–610. Link to PDF.

Link to:  Reproducible and Scalable Synthesis of End-Cap-Functionalized Depolymerizable Poly(phthalaldehydes)

20. "Reproducible and Scalable Synthesis of End-Cap-Functionalized Depolymerizable Poly(phthalaldehydes)", DiLauro, A.; Robbins, J. S.; Phillips, S. T.*, Macromolecules, 2013, 46, 2963–2968. Link to PDF. Highlighted in Synfacts 2013, 9, 0725.

Link to: Effects of Electronics, Aromaticity, and Solvent Polarity on the Rate of Azaquinone-Methide-Mediated Depolymerization of Aromatic Carbamate Oligomers

19. "Effects of Electronics, Aromaticity, and Solvent Polarity on the Rate of Azaquinone-Methide-Mediated Depolymerization of Aromatic Carbamate Oligomers", Robbins, J. S.; Schmid, K. M; Phillips, S. T.*, J. Org. Chem., 2013, 78, 3159–3169. Link to PDF.

Link to: Two General Designs for Fluidic Batteries in Paper-Based Microfluidic Devices That Provide Predictable and Tunable Sources of Power for On-Chip Assays

18. "Two General Designs for Fluidic Batteries in Paper-Based Microfluidic Devices That Provide Predictable and Tunable Sources of Power for On-Chip Assays", Thom, N. K.; Lewis, G. G.; DiTucci, M. J.; Phillips, S. T.*, RSC Adv., 2013, 3, 6888–6895. Link to PDF.

17. Phillips, S. T.*; Thom, N. K., "Three-Dimensional, Paper-Based Microfluidic Devices Containing Internal Timers for Running Time-Based Diagnostic Assays"in Microfluidic Diagnostics, Methods and Protocols; Jenkins, G.; Mansfield, C. D., Eds.; Methods in Molecular Biology 949; Springer: New York, 2013; pp 185–196. Link to PDF

Link to: A Thermally-Stable Enzyme Detection Assay that Amplifies Signal Autonomously in Water Without Assistance from Biological Reagents

16. "A Thermally-Stable Enzyme Detection Assay that Amplifies Signal Autonomously in Water Without Assistance from Biological Reagents", Yeung, K.; Schmid, K. M.; Phillips, S. T.*, Chem. Commun., 2013, 49, 394–396. Link to PDF.

Link to: Phase Switching to Enable Highly Selective Activity-Based Assays

15. "Phase Switching to Enable Highly Selective Activity-Based Assays", Mohapatra, H.; Phillips, S. T.*, Anal. Chem., 2012, 84, 8927–8931. Link to PDF.

Link to: Quantifying Analytes in Paper-Based Microfluidic Devices Without Using External Electronic Readers

14. "Quantifying Analytes in Paper-Based Microfluidic Devices Without Using External Electronic Readers", Lewis, G. G.; DiTucci, M. J.; Phillips, S. T.*, Angew. Chem. Int. Ed., 2012, 51, 12707–12710. Link to PDF.

Link to: Using Smell to Triage Samples in Point-of-Care Assays

13. "Using Smell to Triage Samples in Point-of-Care Assays", Mohapatra, H.; Phillips, S. T.*, Angew. Chem. Int. Ed., 2012, 51, 11145.–11148. Link to PDF.

Link to:High Throughput Method for Prototyping Three-Dimensional, Paper-Based Microfluidic Devices

12. "High Throughput Method for Prototyping Three-Dimensional, Paper-Based Microfluidic Devices", Lewis, G. G.; DiTucci, M. J.; Baker, M. S.; Phillips, S. T.*, Lab Chip, 2012, 12, 2630–2633. Link to PDF. One of the top ten most accessed articles in Lab on a Chip in June 2012.

Link to: A Self-Immolative Spacer that Enables Tunable Controlled Release of Phenols under Neutral Conditions

11. "A Self-Immolative Spacer that Enables Tunable Controlled Release of Phenols under Neutral Conditions", Schmid, K. M.; Jensen, L.; Phillips, S. T.*, J. Org. Chem., 2012, 77, 4363–4374. Link to PDF.

Link to: A Small Molecule Sensor for Fluoride Based on an Autoinductive, Colorimetric Signal Amplification Reaction

10. "A Small Molecule Sensor for Fluoride Based on an Autoinductive, Colorimetric Signal Amplification Reaction", Baker, M. S.; Phillips, S. T.*, Org. Biomol. Chem., 2012, 10, 3595–3599. Link to PDF.

Link to: Fluidic Batteries in Paper-Based Microfluidic Devices

9. "Fluidic Batteries in Paper-Based Microfluidic Devices", Thom, N. K.; Yeung, K.; Pillion, M. B.; Phillips, S. T.*, Lab Chip, 2012, 12, 1768–1770. Link to PDF. Selected as a "Hot Paper" by the editors of Lab on a Chip. One of the top ten most accessed articles in Lab on a Chip in March 2012. Selected as one of the top 10% of all Lab on a Chip articles published this year.

Link to: Design of Small Molecule Reagents that Enable Signal Amplification via an Autocatalytic, Base-Mediated Cascade Elimination Reaction

8. "Design of small molecule reagents that enable signal amplification via an autocatalytic, base-mediated cascade elimination reaction", Mohapatra, H.; Schmid, K. M.; Phillips, S. T.*, Chem. Commun., 2012, 48, 3018–3020. Link to PDF.

Link to:Self-Powered Microscale Pumps Based on Analyte-Initiated Depolymerization Reactions

7. "Self-Powered Microscale Pumps Based on Analyte-Initiated Depolymerization Reactions", Zhang, H.; Yeung, K.; Robbins, J. S.; Pavlick, R. A.; Wu, M.; Liu, R.; Sen*, A.; Phillips, S. T.*, Angew. Chem. Int. Ed., 2012, 51, 2400–2404. Link to PDF. Selected as a "Hot Paper" by the editors of Angewandte Chemie. Highlighted in: Chemistry World.

Link to:A Structurally Simple Self-Immolative Reagent That Provides Three Distinct, Simultaneous Responses per Detection Event

6. "A Structurally Simple Self-Immolative Reagent That Provides Three Distinct, Simultaneous Responses per Detection Event", Nuñez, S. A.; Yeung, K.; Fox, N. S.; Phillips, S. T.*, J. Org. Chem., 2011, 76, 10099–101131. Link to PDF

Link to:Use of Catalytic Fluoride under Neutral Conditions for Cleaving Silicon-OxygenBonds

5. "Use of Catalytic Fluoride under Neutral Conditions for Cleaving Silicon-Oxygen Bonds", DiLauro, A.; Seo, W.; Phillips, S. T.*, J. Org. Chem., 2011, 76, 7352–7358. Link to PDF. Highlighted in: ChemInform 2012, Organic Chemistry Portal, and GalChimia.

Link to: A Two-Component Small Molecule System for Activity-Based Detection and Signal Amplification: Application to the Visual Detection of Threshold Levels of Pd(II)

4. "A Two-Component Small Molecule System for Activity-Based Detection and Signal Amplification: Application to the Visual Detection of Threshold Levels of Pd(II)", Baker, M.S.; Phillips, S. T.*, J. Am. Chem. Soc., 2011, 133, 5170–5173. Link to PDF. Highlighted in: Chemistry & Engineering News.

Link to: Fluidic Timers for Paper-Based Microfluidic Devices

3. "Fluidic "Timers" for Paper-Based Microfluidic Devices", Noh, H., Phillips, S. T.*, Anal. Chem, 2010, 82, 8071–8078. Link to PDF. Highlighted in: Chemistry & Engineering News, Philadelphia Inquirer, USA Today, Gizmag Emerging Technology Magazine, Science Magazine: Science Daily News, Technology Daily: Style and Reviews Daily News Magazine, Science Daily, Oil & Gas Industry Today: Paraffin News, Medindia.net, Laboratory Equipment.com, Smart-Grid.tmcnet.com, Justmeans, Internet Chemistry.com, Fluidics: Microfluidics News, Physorg.com, Indiaofs.com, International Hospital, Latest Technology Blog, Lower my Cholesterol.net, Health.gresnews.com, Examiner.com, Health Info Here, Digg.com.

Link to: Patterned Plastics that Change Physical Structure in Response to Applied Chemical Signals

2. "Patterned Plastics that Change Physical Structure in Response to Applied Chemical Signals", Seo, W.; Phillips, S. T.*, J. Am. Chem. Soc., 2010, 132, 9234–9235. Link to PDF. Highlighted in: Nature Chemistry, and twice in New Scientist (June 28, 2010 and June 30, 2010), European Plastics News, SYNFACTS, JACS Select, Plastics News.com, Green Earth Africa, Platinum Today, Iran Daily, Techmonitor.net, Carbon Capture Report, Chemistry in the News: Exploring Chemistry, Renewable Energy Blog.

Link to: Metering the Capillary-driven Flow of Fluids in Paper-Based Microfluidic Devices

1. "Metering the Capillary-driven Flow of Fluids in Paper-Based Microfluidic Devices", Noh, H., Phillips, S. T.*, Anal. Chem., 2010, 82, 4181–4187. Link to PDF

Prior Publications


29. "Measuring Markers of Liver Function Using Micro-Patterned Paper and Blood Obtained From a Finger Prick", Vella, S.; Cademartiri, R.; Laromaine, A.; Beattie, P.; Martinez, A.; Phillips, S. T.; Mirica, K.; Whitesides, G. M., Anal. Chem., DOI: 10.1021/ac203434x. Highlighted in: Chemistry and Engineering News.

28. "Measuring Binding of Protein to Gel-Bound Ligands with Magnetic Levitation", Shapiro, N.; Mirica, K.; Soh, S.; Phillips, S. T.; Taran, O.; Mace, C.; Shevkoplyas, S.; Whitesides, G. M.*, J. Am. Chem. Soc., accepted.

27. "A Sliding-Strip Microfluidic Paper-Based Device for ELISA", Liu, X.; Cheng, C.-M.; Martinez, A. W.; Mirica, K. A.; Phillips, S. T.; Mascareñas, Whitesides, G. M.*,submitted.

26. "Millimeter-Scale Contact Printing of Aqueous Solutions using a Stamp Made out of Paper and Tape", Cheng, C.-M.; Gong, J.; Martinez, A. W.; Mazzeo, A. D.; Phillips, S. T.; Jain, N.; Whitesides, G. M.*, Lab Chip, DOI: 10.1039/C004903D.

25. "Programmable Diagnostic Devices Made from Paper and Tape", Martinez, A. W.; Phillips, S. T.; Jain, N.; Whitesides, G. M.*, Lab Chip, 2010, 10, 2499–2504. Highlighted in: Chemical Technology - RSC (Royal Society of Chemistry); one of the top ten most accessed articles in Lab Chip for the month of August, 2010.

24. "Magnetic Levitation in Analysis of Foods and Water", Mirica, K. A., Phillips, S. T., Mace, C. R., Whitesides, G. M.*, J. Agric. Food Chem., 2010, 58, 6565–6569. Highlighted in: Chemistry & Engineering News, National Public Radio (NPR), The Economist, Wissenschaft aktuell Nachrichten, SciDev.Net, ACS press release, e!Science News, Science Daily, InventorSpot, newsfood.com, medicalnewstoday.com, foodproductiondaily.com, beforeitsnews.com, Health Jockey, gizmag.com.

23. "Paper-Based ELISA", Cheng, C., Martinez, A. W., Gong, J., Mace, C. R., Phillips, S. T., Carrilho, E., Mirica, K. A., Whitesides, G. M.*, Angew. Chem. Int. Ed., 2010, 49, 4771–4774.

22. "Co-Fabrication: A Strategy for Building Multi-Component Microsystems", Siegel, A. C.; Tang, S. K. Y.; Nijhuis, C. A.; Hashimoto, M.; Phillips, S. T.; Dickey, M. D.; Whitesides, G. M.*, Acc. Chem. Res. 2010, 43, 518–528.

21. "Folded Printed Circuit Boards on Paper Substrates", Siegel, A. C.; Phillips, S. T.; Dickey, M.; Lu, N.; Suo, Z.; Whitesides, G. M.*, Adv. Funct. Mat., 2010, 20, 28–35.

20. "Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices", Martinez, A. W.; Phillips, S. T.; Carrilho, E.; Whitesides, G. M.* Anal. Chem. 2010, 82, 3–10.

19. "Quantifying Colorimetric Assays in Paper-Based Microfluidic Devices by Measuring the Transmission of Light through Paper", Ellerbee, A. K.; Phillips, S. T.; Siegel, A. C.; Mirica, K. A.; Martinez, A. W.; Striehl, P.; Jain, N.; Prentiss, M.; Whitesides, G. M.*, Anal. Chem., 2009, 81, 8447–8452.

18. "Measuring Densities of Solids and Liquids Using Magnetic Levitation: Fundamentals", Mirica, K. A.; Shevkoplyas, S. S.; Phillips, S. T.; Gupta, M.; Whitesides, G. M.*, J. Am. Chem. Soc., 2009, 131, 10049–10058.

17. "Paper Microzone Plates", Carrilho, E.; Phillips, S. T.; Vella, S. J.; Martinez, A. W.; Whitesides, G. M.*, Anal. Chem., 2009, 81, 5990–5998. Highlighted in: Anal. Chem.

16. "Thin, Lightweight, Foldable Thermochromic Displays on Paper", Siegel, A. C.; Phillips, S. T.; Wiley, B.; Whitesides, G. M.*, Lab Chip, 2009, 9, 2775–2781. Highlighted in: Chemistry Technology, Chemistry World, and Wired Science.

15. "Using Magnetic Levitation to Distinguish Atomic-Level Differences in Chemical Composition of Polymers, and to Monitor Chemical Reactions on Solid Supports", Mirica, K. A.; Phillips, S. T.; Whitesides, G. M.*, J. Am. Chem. Soc., 2008, 103, 17678–17680. Highlighted in Nature Chemistry.

14. "3D Microfluidic Devices Fabricated in Layered Paper and Tape", Martinez, A.; Phillips, S. T.; Whitesides, G. M.*, Proc. Natl. Acad. Sci., U.S.A. 2008, 105, 19606–19611. Highlighted in: Technology Review; The Scientist; Wired Science; IEEE spectrum online; Nature;Science; New Scientist; Discover Magazine; Physics Today; Thaindin News; America.gov; Small Times; Science News; New York Times; Boston Globe; Chisblassternardone; International Herald Tribune; Financial Times Deutschland;The Harvard University Gazette.

13. "FLASH: A Rapid Method for Prototyping Paper-Based Microfluidic Devices", Martinez, A.; Phillips, S. T.; Wiley, B.; Whitesides, G. M.*, Lab Chip, 2008, 8, 2146–2150.Highlighted in: Chemical Technology - RSC (Royal Society of Chemistry); Nature Chemistry; New Scientist Tech; Journal of Chemical Education, published by the Division of Chemical Education of the American Chemical Society, called Research Advances (RA); ranked as the most accessed article in Lab on a Chip for September 2008.

12. "Simple Telemedicine for Developing Regions: Camera Phones and Paper-Based Microfluidic Devices for Real-Time, Off-Site Diagnosis", Martinez A.; Phillips, S. T.; Thomas, S. W.; Sindi, H.; Whitesides, G. M.*, Anal. Chem. 2008, 80, 3699–3707.

11. "Density-Based Diamagnetic Separation: Devices for Detecting Binding Events and for Collecting Unlabeled Diamagnetic Particles in Paramagnetic Solutions", Winkleman, A.; Perez-Castillejos, R.; Gudikson, R.; Phillips, S. T.; Prentiss, M.; Whitesides, G. M.* Anal. Chem. 2007, 79, 6542–6550.

10. "Ritterazine Natural Products: Synthesis, Kinetic Analysis, and Reassignment of Ritterazine 5,5-Spiroketals" Phillips, S. T.; Shair, M. D.*, J. Am. Chem. Soc. 2007, 129, 6589–6598.

9. "Patterned Paper as a Platform for Inexpensive, Low Volume, and Portable Bioassays", Martinez, A.; Phillips, S. T.; Butte, M.; Whitesides, G. M.*, Angew. Chem. Int. Ed., Eng. 2007, 46, 1318–1320. Highlighted in: Nature, Chem. Eng. News, Anal. Chem., and other journals. *This body of work was chosen as a 2009 Breakthrough of the Year by Popular Mechanics.*

8. "Quantifying the Interactions that Contribute to beta-Hairpin Folding" Phillips, S. T.; Piersanti, G.; Bartlett, P. A.*, Proc. Natl. Acad. Sci. USA 2005, 102, 13737–13742.

7. "@-Tides as Reporters for Molecular Associations" Phillips, S. T.; Blasdel, L. K.; Bartlett, P. A.*, J. Am. Chem. Soc. 2005, 127, 4193–4198.

6. "@-Tide-Stabilized beta-Hairpins" Phillips, S. T.; Blasdel, L. K.; Bartlett, P. A.*, J. Org. Chem. 2005, 70, 1865–1871.

5. "Facile Synthesis of @-Tide beta-Strand Peptidomimetics: Improved Assembly in Solution and on Solid Phase" Phillips, S. T.; Piersanti, G.; Rüth M.; Gubernator, N.; van Lengerich, B.; Bartlett, P. A.*, Org. Lett. 2004, 6, 4483–4485.

4. "@-Tides: The 1,2-Dihydro-3(6H)-pyridinone Unit as a beta-Strand Mimic," Phillips, S. T.; Rezac, M.; Abel, U.; Kossenjans, M.; Bartlett, P. A.*, J. Am. Chem. Soc. 2002, 124, 58–66.

3. "Avocadofurans and Their Tetrahydrofuran Analogs: Double Bonds are Critical for Toxicity to Insects", Rodriguez-Saona C. R.; Phillips, S. T.; Maynard, D. F.; Trumble, J. A.*, J. Agric. Food Chem. 2000, 48, 3642–3645.

2. "Effects of Alkyl Side-Chain Length on Insecticidal Activity" Rodriguez-Saona, C. R.; Maynard, D. F.; Phillips, S. T.; Trumble, J. A.* , J. Nat. Prod. 1999, 62, 191–193.

1. "Yeast Protein Farnesyltransferase. Binding of S-Alkyl Peptides and Related Analogs", Rozema D. B.; Phillips, S. T.; Poulter, C. D.*, Org. Lett. 1999, 1, 815–817.

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