Woman finds new life in heart valve device made at Hershey Medical Center

Denise Brown, left, talks to Dr. John Conte about how she feels since he implanted an apical aortic conduit into her heart last February. Credit: Penn State Health / Penn StateCreative Commons

Denise Brown is no stranger to adversity. Incredibly, she battled four types of cancer by the time she turned 3 years old.

Her latest triumph is overcoming life-threatening heart valve surgery, which, she says, is thanks to God—and this time—to Dr. John Conte, program director, cardiac surgery at Penn State Health Milton S. Hershey Medical Center.

“I kind of felt like I was unworthy,” said the 49-year-old New Jersey resident. “I said ‘Why me?’ He said, ‘You can’t live without it.’ I felt like a princess getting her pony for the first time.”

Because existing valve options wouldn’t fit Brown’s underdeveloped left ventricle, scarred from radiation, Conte sought special permission from the U.S. Food and Drug Administration (FDA) to reconfigure an old device. Next, he approached the Milton S. Hershey Medical Center’s Division of Applied Biomedical Engineering to produce it.

Last February, Conte implanted the apical aortic conduit into Brown’s heart, allowing blood to flow once again—along with hope and gratitude.

“I’ve told Dr. Conte many times that he saved my life,” Brown said. “I don’t know many doctors that would have made something for somebody they don’t even know, let alone such a high-risk patient. He was the answer to my prayers.”

Her childhood cancers have haunted her life in many ways—from the taunts of other children and feelings of inferiority to physical ailments that curtailed her plans and dreams.

At 18 months of age, Brown was diagnosed with non-Hodgkin lymphoma, a cancer that develops in the lymph nodes and lymphatic tissue. Within the year, she was diagnosed with bone marrow cancer. At age 3, a mass in her right breast revealed early stages of breast cancer. Shortly after that came the diagnosis of leukemia. Because her immune system was low, she contracted tuberculosis.

“I was in and out of the hospital constantly for the first six years of my life,” Brown said. “Every week I was having chemo, radiation or cobalt treatments.”

Those six years of treatments scarred her heart valves, compromised her lungs and led to advanced coronary disease, as well as disease of her aorta and blood vessels leading to her brain.

In 2011, she was diagnosed with aortic stenosis, a narrowing of the aortic valve. That’s a problem because the aorta is the main artery that carries blood to the rest of the body.

After several years of seeing doctors at various medical centers for valve replacement evaluations, Brown met Conte at Johns Hopkins in Baltimore in 2016. Remembering the surgeries he did before transcatheter valves took their place, Conte began looking worldwide for an apical connector he thought would work but wasn’t made anymore. Shortly after that, Conte left for Hershey Medical Center, and—desperate for help—Brown followed him.

“He was the only doctor who knew my situation and was willing to do what it took to help me,” Brown said. “I trusted him because he knew what size valve I needed and how sensitive the surgery was going to be.”

“I guess there aren’t many doctors who had the experience doing this surgery and were lucky enough to be at an institution where you could propose something like this and receive support throughout the regulatory process,” Conte said. “All the stars had to align.”

Read more of Denise’s story in this Penn State Medicine article.

When it seemed 49-year-old Denise Brown was out of options for a much-needed valve repair, Dr. John Conte, cardiac surgery program director at Penn State Health Milton S. Hershey Medical Center, stepped in with an innovative solution that Denise says saved her life. 

Last Updated November 28, 2018